We hear about opioid overdose deaths everyday in the US, but there’s a whole other downside to remember: the effects of long-term opioid use on health in general. So aside from falling down dead from overloading the system, here are some other things that can be expected if you’re popping these pills for years at a time.
Well, what about that overdose risk?
Obviously, ancillary medical problems are an issue, but what we hear about most are not the long-term effects of opioid use, but of the more immediate overdose issue. How much of an issue is this? Well pretty big, and growing at an incredibly fast rate. In fact, that’s part of the general scariness of this issue, not that it exists, but that it seems to grow massively at every juncture.
The last numbers put out on the issue came from preliminary data released by the CDC for 2021. According to this data, there were approximately 107,000 overdose deaths in 2021, up from 93,000 in 2020, and 71,000 in 2019. These numbers account for all overdose deaths from illicit drugs, but we know opioids make up the lion’s share of them. Though we don’t have a more specific breakdown for 2021, we know that of the 93,000 of 2020, that about 68,000 were related to opioids. And that of 2019 numbers, about 48,000 of the deaths came from synthetic opioids. For comparison, that year, there were less than 15,000 heroin overdoses.
This problem has gotten so out of hand, that states like New York and Rhode Island are already instituting safe-use site measures to give those in need, a safe place to use their drugs. Along with testing to ensure no fentanyl, emergency services, and other social services.
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It’s even got to the point that some places, like British Columbia, in Canada, are working to decriminalize all drugs, just to make it easier for people using opioids, to do what they have to without further punishment. Whether these are actually measures to help people, though, is questionable, as they mainly seek to promote the general problem, rather than finding ways to fix it.
If you want to know how ubiquitous needle disposal apparatus is in America, consider that at this year’s MJBizCon, which took place in the Convention Center of Las Vegas, there were needle depositories in the women’s bathroom. Apparently it’s expected that literally anywhere, someone may need to get rid of needles.
Damage from long-term opioid use: colon
Maybe you started on opioids the way many people do, to deal with a pain issue. And maybe you’re one of those people that loves the way the drugs feel. It almost doesn’t matter why a person started if they’re going to take them for years of time. Maybe you’re one of those people who takes them in a controlled enough way that you don’t have to worry about overdosing on them. Well, hate to break it to you, but these are hardcore medications that your body doesn’t expect to deal with, and they come with a myriad of long-term health issues, which vary by user.
One of the big problems, is issues in the gut. Opioids decrease general activity in the guts, which is why another one of their uses is for diarrhea. It essentially works to control it, and in doing so, can create constipation instead. This effect of creating constipation isn’t acclimated to, and in fact, tends to get worse over time. Meaning long-term opioid users can develop different issues related to their guts and colon.
Take Matthew Perry, for example, who we all know as Chandler from the long-running Friends. Throughout his professional life we’ve heard different stories of his issues with drugs, but perhaps the most daunting came recently from an autobiography he put out. In it, he details how his colon burst as a result of opioid activity in the guts. In his case, the incident led to a two-week coma, and nine-months with a colostomy bag. For anyone unfamiliar with the latter term, it’s a bag worn outside the body, which is hooked up directly to the body, and which collects the feces, as they can no longer go through the damaged colon. Sound like a fun way to conduct your social life?
This happens due to the colon stretching out of shape, which it can’t always heal from. If a person already has a bowel issue, opioids can make it worse, even causing perforations, which is apparently how Perry ended up in the situation he did. What happened to Perry might be one of the rarer cases, but with increased use of these medications, rare cases become more of a norm.
Damage from long-term opioid use: blood-oxygen levels and endocrine system
Many aspects of opioids are acclimated to with regular use. This unfortunately can include the effects on pain and sedation, but doesn’t include the effects on breathing. Opioid are known for depressing the respiratory center of the brain, the part that controls breathing. If enough is taken, a person can stop breathing, and this is how many people overdose.
However, even if a person doesn’t die, this can also lead to lowered blood-oxygen levels. This happens a lot when doses are increased, which becomes standard for these medications since other effects, like pain-relieving effects, are acclimated to, leading to a need for more to get the same relief. As large increases are often experienced in a short period of time, this creates a problem with users having low blood-oxygen levels.
And then there are the effects on testosterone. Called hypogonadism, this applies to both men and women with extended use of the medications, and means a fall in testosterone levels. As these issues become more evident through time and increased overall use of the medications, this issue has presented itself, but with little known as to how reversible the effects are.
What has been noticed as well, are symptoms like amenorrhea in women, reduced desire for sex, as well as infertility (in both sexes), and erectile dysfunction in men.
Damage from long-term opioid use: the brain and other issues
Let’s be honest for a second, the reason people often get addicted to opioids, is because they’re affecting the brain, and bringing on feelings of euphoria. Anytime something is taken repeatedly that can impact the brain, there’s a question of what it’s doing long-term. In the case of these meds, perhaps it shouldn’t be surprising that long-term opioid use can cause changes in behavior and cognition, though much is reversible.
In the short term it does get in the way of the ability for concentration, as well as affecting abstract thinking. Not only that, use of the drug can lead to a diminished experience of pleasure, and can cause people to lose interest in activities that used to make them happy.
Another thing often seen, related to the sedation and disorientation effects of the drugs, is simply that people are more likely to hurt themselves. This is seen mainly though falls where bones are fractured or broken. It applies most to the elderly, and is similar to another class of drugs, benzodiazepines, which also cause sedation and disorientation.
Opioids have also shown to have an effect on the immune system and immunity. The immunomodulating effects of the drug, seen in both human and animal studies, effect immune effector cells, as well as the central nervous system, in the form of immunosuppression. This means the immune system is being suppressed, and won’t work as well. In animal studies specifically, opioids have shown to effect antimicrobial response and anti-tumor surveillance in the body.
Just to finish it all off, long-term opioid use can actually do something paradoxical, it can create a greater sensitivity to pain, which, when you think about it, is really not helpful considering their main purpose is in pain suppression. This phenomenon, called hyperalgesia, is generally only seen when there is no tolerance built to the analgesic effects of the meds. This pain doesn’t relate to the original pain suffered, and is generally less-well defined from the original pain issue. No matter how you look at it though, a pain medication that goes on to cause new forms of pain, is certainly not ideal.
Opioids cause much damage, both in the overdose deaths they promote, as well as the long-term issues that come from extended use. More and more, it should be asked why other, less dangerous drugs like ketamine, aren’t immediately being substituted to help ease this growing opioid issue.
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5 Best Clubs in London in 2023
Whether you’re a local or a tourist, knowing the right places to go out is a must. The difference between a good club and a bad one is the difference between an enjoyable night and a night to forget. That is why you need a succinct list that can do the work for you. London is teeming with electric nightlife opportunities and, if you know where to go, you may well have the best evening of your life.
In this article we’re going to go list the 5 best clubs in London and explain just why they’ve made this list. As a Londoner, I myself have gone to each and every one of these and can vouch for their excellence. So, without further ado, welcome to the capital of England.
Whilst there are many cities in the world with incredible nightlife – Las Vegas, Amsterdam, Paris, Barcelona, Ibiza to name a few – London holds its own in the competition. This city is known for having some of the best nightlife in the world for several reasons. One of the main reasons is the city’s diversity. There are over 300 different languages spoken every day, with 1 out of every 3 Londoners being born abroad.
The city is a melting pot of cultures, which means that there is a wide variety of clubs and bars to choose from, each with its own unique atmosphere and music. Every type of musical genre is covered, and every demographic is catered for. However you identify – sexuality, gender, race or age – there should be something for you in London. This brings us to our next point.
Another reason for London’s incredible nightlife is the city’s large population. With a population of over 8 million people, there is always a high demand. This has led to the development of a thriving club and bar scene, with new venues opening up all the time. This also attracts some of the best DJ’s and musicians in London to these locations, such as Berlin techno artists.
London is also known for its strict licensing laws, which require clubs and bars to close at a certain time. This has led to the development of late-night clubs that are open until the early hours of the morning, catering to those who want to party all night long. So, let’s bring back the energy of the 90s rave scene and find out the best clubs in London in 2023 to party at.
London: 5 Best Clubs
Whether you’re someone who wants something chill or something hard, London caters to all. Maybe you like pop music, jazz, cuban, or even just the repetitive sounds of techno, anything is possible in the big city. There are countless clubs and bars to choose from, making it difficult to narrow down the best options. I have done my fair share of clubbing over the years and I’ve had nights to remember and nights to forget. But are the 5 clubs in London that will surely create a memorable evening.
1 – Fabric
It is hard to speak about London nightlife without mentioning Fabric. This place has closed and reopened many times but, as it stands, this iconic spot has its doors wide open. Located in the heart of London, Fabric is a club that is known for its electronic dance music (EDM) scene. The club has a winding design, with corridors seeming to lead to nowhere. But actually, this is to avoid having any corners to hide and do drugs behind – they are very strict on this in Fabric. Although, of course, everyone still does it.
There are three main rooms, each with its own unique sound system and atmosphere. The main room is known for its techno and house music, while the second room features drum and bass and the third room is known for its grime and hip-hop. Fabric also has a mezzanine level where you can take a break from dancing and get a drink.
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The club is open until 6am on Friday and Saturday nights, making it the perfect place to party all night long. For me, Fabric was a coming of age place, somewhere that you had to go to in order to truly become a young adult. The night was magical – a pinger, some hard EDM and a lot of hugs with my friends – it was one I knew I’d never forget. Whilst Fabric is intense, it’s a place you need to go at least once in your life.
2 – Fold
If you’re looking for relentless, meditative techno all night and all day then Fold is the place for you. You’ll go into a trance that you may never wake up from. Located in hipster East London, Fold is hosted in an old warehouse on the river. It isn’t the nicest looking building, but if you’re used to the Berlin techno scene then you’ll feel right at home. There’s the usual Fold events, which happen on weekend evenings, and then there’s UnFold, which is a day event on a Sunday.
This is for those who want to keep going. This club is full of tech-heads, many people wearing crazy outfits and chokers. As I said previously, it’s the usual techno aesthetic that you may see at the Berghain in Berlin. When I first went to Fold I was a little skeptical, unsure if I could realistically listen to repetitive techno all night long. But one of the best DJs in Berlin was playing – Patrick Mason – and his performance was something of legend. The music lulled me to another world – I will never forget that night. Since then, I’ve loved Fold and everything it stands for.
3 – XOYO
If you’re looking for something a little more colorful and vibrant, XOYO may be the perfect place for you. This club is less specific, and plays a vast range of music, making it open to anyone and everyone. XOYO is located in the heart of Shoreditch and is known for its eclectic mix of music. The club has two rooms, one featuring house and techno music and the other featuring live performances from up-and-coming artists. XOYO is open until 4am on Friday and Saturday nights, making it a great place to go if you want to party but don’t want to stay out all night. It’s also right next to Old Street, making it a very easy place to access. Shoreditch is full of bars and fun things to do too, so you can easily have pre drinks before heading to OXYO.
4 – Dalston Jazz Bar
If you’re looking for something a little more quaint, small and intimate, then the legendary Dalston Jazz Bar is ideal. Situated in another hipster spot in East London, this place is a delicious restaurant in the day, and a live Jazz venue in the evening. The tables get moved away, the kitchens close, the musicians come out, and the cocktails get made. If you’ve never seen live Jazz music in London then there aren’t many better places than this. In addition, the dancing is incredible. Whilst this place is a lot smaller and less known than the others, it deserves its place on this list. It has more soul and character than perhaps all of the others combined. You must go.
5 – Printworks
Opening in 2017, Printworks is the best up and coming venue in London right now. Located in the former printing press building in Canada Water, Printworks is a club that is known for its immersive and innovative events. The club has five main rooms, each featuring a different genre of music. The main room is known for its techno and house music, while the second room features drum and bass, and the third room is known for its grime and hip-hop.
The fourth and fifth rooms are used for special events and live performances. Printworks is open until 6am on Friday and Saturday nights, so definitely caters for those who like long nights. The most eye-catching thing about this venue is the main room. It’s a massive hallway, several stories high, that sort of looks like a prison. Printworks is also attracting some of the best DJs in the world. If you’re wanting to lose yourself then this is the place.
It’s not easy to choose but, overall, these five clubs are some of the best places to party in London. There is something for everyone on this list. If you are planning a night out in London, be sure to check out one of these clubs for an unforgettable party experience. Over the years, I definitely had many in these spots.
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The Lowdown On Syria As The New Captagon Narco State
The Mid-East countries might be outwardly against drugs, but that doesn’t mean their people aren’t using, or involved in the trade. From published research showing the growing trend of hash among youth in Saudi Arabia, to Syria and its new position as a Captagon narco state, it kind of seems like the Mid-East, is right in the middle of it all.
What’s a ‘narco state’?
We hear the term ‘narco state’ a lot, particularly when talking about the international drug trade. For those who don’t follow the news, the word ‘narco’ is still pretty out there, what with the array of television shows portraying the lives of famous illicit drug entrepreneurs. But what exactly does it mean? According to collinsdictionary, it’s pretty simply:
“A country in which the illegal trade in narcotic drugs forms a substantial part of the economy.” That certainly paints a picture, but more in depth definitions explain the concept even better. Oxford reference explains it further, saying,
“A nation state whose government, judiciary, and military have been effectively infiltrated by drug cartels, or where the illegal drug trade is covertly run by elements of the government. It can also refer to a region under the control of organized crime for the purposes of producing or trafficking drugs where legitimate political authority is absent.”
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It then goes on to explain that the term “‘Narco state’ is more a journalistic phrase than an entity under international law. It has been used to describe Colombia, Guinea-Bissau, Suriname, and Mexico at various times….”
Basically, a narco state refers to a situation whereby those who control the drug trade, also hold a substantial power in governance. This generally undermines the political parties and/or laws of a country, often making such entities look rather powerless in comparison (though they’re often involved). Take Mexico, for example. It’s one of the most well-known examples of a country which is essentially run by its criminal organizations, and where very few people expect the government to do much about it.
A country dubbed a ‘narco state’ can go from being a narco state to a non-narco state if the structure that allows the criminal organizations their power, is fundamentally changed. Likewise, a country not known by this term, can easily become associated with it, if for some reason its drug trade is suddenly elevated. Such is the current case with Syria, as the drug Captagon propels it to narco state status.
A country can become a narco state based on the trade of different drugs. Some of the drugs most responsible for incurring large drug trades, include heroine (opium), cocaine (coca), and cannabisThis post contains affiliate links!. But there are plenty more drugs that rise and fall in popularity, and right now, the Mid-East is home to one of the burgeoning drugs to create a narco state – Captagon.
Captagon – or fenethylline – is a codrug and prodrug of amphetamine, meaning it works well with amphetamine, and breaks down into it within the body. It also goes by the spellings phenethylline and fenetylline, and by the names: amphetaminoethyltheophylline and amfetyline. Its been marketed under the names Captagon, Biocapton, and Fitton, as a psychostimulant. And as of now, it comes with no identifiable death toll. At all.
Psychostimulant is a nonspecific word that goes hand in hand with the word ‘uppers’. It applies to drugs that increase activity in the central nervous system, and bring on positive feelings like euphoria. The category includes everything from cocaine, to methamphetamine, to caffeine, to Captagon.
Captagon was first synthesized in 1961 by German chemicals company Degussa AG. For many years it was used as an alternative to amphetamine as it provides a milder response. One of its benefits over amphetamine, is not causing quite as extreme an increase in cardiovascular function. Even as it proved safer than amphetamine, and enjoyed use as a medication for narcolepsy, ADHD, and depression; the US illegalized it, putting in Schedule I of the Controlled Substances list in 1981.
This was followed up in 1986 by the World Health Organization adding it to the Convention on Psychotropic Substances, essentially leading to its illegalization in much of the world. And this while amphetamine remained legal, with Schedule II designation in the US. Though the drug certainly exists in many places, it’s found most in the countries of the Middle East. Like most any illicit drug industry, this also means the trafficking and sale of counterfeit Captagon.
As is stands now, Saudi Arabia is one of the biggest Captagon consumers, and the majority of the drug gets trafficked in through Syria. The industry has grown so exponentially in the country, that Syria has become a Captagon narco state.
Syria and Captagon
Syria – the Syrian Arab Republic – sits in Western Asia. To its west are the Mediterranean, Turkey, Lebanon, and Israel; to its south is Jordon; to its south and east is Iraq; and to its north is also Turkey. Arabs are the largest ethic group in the country, but are joined by Kurds, Turkmens, Assyrians, Armenians, Circassians, Albanians, and Greeks. The most common religion is Muslim, but there are also plenty of Christians, Alawites, Druze, and Yazidis.
Since March of 2011, there’s been civil war in Syria, mostly because of the leadership of Bashar al-Assad, who took over in 2000, upon the death of his father Hafez al-Assad. The current leadership has been roundly associated with human rights abuses like executions of political prisoners, and wide-ranging censorship. Assad’s rule is challenged by political groups like Syrian Interim Government, Syrian Salvation Government, and Rojava. This civil war has claimed the lives of over a half million people, and led to a refugee crisis involving upwards of seven million displaced residents, and around five million refugees.
All of this is important because it shows the instability of the leadership of the country. Captagon at one point was associated with Islamic State fighters (part of the a militant Islamist group that promotes the Salafi jihadist branch of Sunni Islam), which makes it less surprising that its manufacture and use has spread so far. In fact, this illegal $10 billion/year industry is directly tied to al-Assad…as well as his enemies. According to international French news agency Agence France-Presse (AFP), Captagon exports dwarf all legal exports out of the country.
Now, to be clear, there are no hard numbers for an illegal drug industry, or at least none that get reported. The size of an illegal industry is approximated through drug busts and seizures. Which realistically means that a country that puts more effort into rooting out drugs and making seizures, could look to have a bigger industry than a country with more drugs, but less push to catch them. It’s said that Syria is the biggest producer and Saudi Arabia the biggest importer, but these assumptions are only based on who has been caught.
In the case of Captagon, its approximated that pills average at about $5. A real Captagon pill costs approximately $25 on the high end, while a knockoff can be as low as $1. In 2021, 460 million pills were taken in seizures, which leads to the total estimate of 2.3 billion pills produced, if 80-90% of trades go through. And this accounts for about $10+ billion in revenue. It’s expected that for every shipment which gets intercepted, that nine others likely make it alright. In reality, the $10 billion estimated from 2021, is probably a low number.
Whether Syria really is the biggest narco state, is arguable at best. Though it makes for killer headlines, its hard to imagine Syria outdoing a country like Mexico. Even so, the real meat of the story, is simply that the growing popularity of Captagon, has led Syria to join the list of countries considered narco states.
Further details of Syria and its relationship with Captagon
Captagon has its place in Syria as a party drug, but its cheapness, and ability for discretion make it a popular choice over the more socially unacceptable alcohol. As the kind of stimulant associated with pulling an all-nighter in school, and for helping soldiers fight longer, its not shocking its used by workers who want to get more work done. There are even stories of bosses spiking their worker’s drinks with the pills, in order to get more work out of them.
France24 spoke with several illegal operators out of Syria, and though most required anonymity, they were able to shed some light on the situation. Said one fixer and trafficker, a big shipment is usually organized by five or six different entities in order to cover the cost of the raw materials, transporting, and necessary bribes; all of which can total around $10 million.
He explained, “The cost is low and the profits high,” and that getting intercepted sometimes isn’t the worst thing because even just one shipment out of ten making it, means enough profit for all involved. In terms of who these people are, he explained “There’s a group of more than 50 barons… They are one big web, Syrians, Lebanese and Saudis.”
Though the Syrian government plays some role (or at least takes money from it), much of the trade happens through Bedouin confederation Bani Khaled, which can often support the entire process of production in Syria, through delivery in a country like Saudi Arabia. This means less hand offs between different organizations, and an easier ability to maintain control. As the network reaches to Jordan, Iraq and Saudi Arabia, from Syria and Lebanon, this gives a large area to work within with one entity overseeing it.
Syria is currently the biggest producer of Captagon, manufacturing approximately 80% of the circulating Captagon globally. This is according to security services, that go on to say that the Captagon trade is worth three times the entire Syrian national budget. Assad-controlled areas are some of the biggest hotspots for this trade, though Assad’s brother Maher al-Assad plays a role as well, and is said to be one of the biggest winners in the Captagon game. It’s reported that many labs get “the raw material directly from the 4th Division, sometimes in military bags,” of which Maher is the de facto head.
The trade has done well to build up groups like Hezbollah, which is said to play a part in patrolling the Lebanese border to ensure safe trafficking. Said an ex-Syrian government adviser who remains anonymous, “Syria is in dire need of foreign currency, and this industry is capable of filling the treasury through a shadow economy from importing raw materials to manufacturing and finally exporting.”
The trade is big enough that many other organizations, including rebel groups, are in on it, particularly in the south of Syria. Sweida and Daraa, two provinces along the border with Jordan, have smuggling routes to Saudi Arabia. Abu Timur, a spokesman for the armed group Al-Karama, explained,
“The smuggling is organized by the tribes who live in the desert in coordination with over 100 small armed gangs,” and that “Captagon brought together all the warring parties of the conflict… The government, the opposition, the Kurds and ISIS.”
Syria might be the new Captagon narco state, but the drug isn’t killing anyone. If you look up ‘Captagon deaths,’ nothing comes up; which greatly begs the question why this matters. Why would anyone go this far to care about something not causing a problem? The only real assumption, is money. The situation has now gone so far, that this no death-toll drug, is reason for a shoot-to-kill policy in Jordan, concerning traffickers of Captagon out of Syria. Meaning a drug that doesn’t kill anyone (much like cannabisThis post contains affiliate links!), is now the reason for many deaths.
While its always nice to see different sides come together, perhaps the pursuance of a drug trade isn’t the best reason. However, low-grade knock-offs aside, Captagon isn’t the most intense drug, and far better than other options like opioids, which cause many deaths.
If you had the choice, you’d probably prefer your kid took a couple Captagon pills, over ever popping a fentanyl; but today’s reality is that you can get shot and killed over a drug, that doesn’t actually kill anyone.
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Meet Psilomethoxin, the Love Child of Psilocybin and 5-MeO-DMT
As unbelievable as it may seem, a new hallucinogen is emerging that utilizes magic mushroom mycelium to essentially create an orally active form of 5-MeO-DMT. It’s known as Psilomethoxin, and this novel discovery is not only exciting on the basis of the compound itself, but it also represents a special union of nature, spirit, and science. This could also be a serious game-changer for the future of synthetic psychedelic production.
What is Psilomethoxin?
Psilomethoxin (4-OH-5-MeO-DMT) is a new tryptamine created in vivo using magic mushroom mycelium. After inoculation, and before the fruiting stage, 5-MeO-DMT is fed into the mushroom substrate, and once the flush comes in, the fruiting bodies contain Psilomethoxin rather than psilocybin or psilocin. It can be made by mixing a pure freebase powder into the substrate, or using a liquid hydrochloride solution. Psilomethoxin is not a scheduled substance, making it federally legal to possess and consume.
4-OH-5-MeO-DMT is an orally active version of classic 5-MeO-DMT (toad venom) with a longer half live. A drug’s half-life refers to the time it takes for the amount of the active substance in your body to reduce by half. Initial reports indicate that the high from psilomethoxin is very different from both 5-MeO and psilocybin.
The high is said to be slightly less intense than 5-MeO (in terms of visual and auditory hallucinations), but the trip lasts much longer. Because it seems like a lot of the psilocybin is canceled out during the cultivation process, the longer high could be simply due to the method of consumption, rather than the addition of mushroom compounds. The effects from cannabisThis post contains affiliate links! edibles lasts longer than those from smoking as well, so it’s not uncommon.
The Church of Psilomethoxin and history behind this compound
Psilomethoxin was initially discovered and synthesized by researchers from the Pasteur Institute, led by Marc Julia, in 1965. The Pasteur Institute, founded in 1887, is French, non-profit center for biomedical research. It was named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies.
The researchers obtained a patent for psilomethoxin, but due to the passing of the Controlled Substances Act in the 1970s, research came to a screeching halt and the patent lapsed after 20 years. The chemists who work with the compound also claim that the process of synthesizing it is very elaborate and time-consuming, which can explain why it remained uncommon for so long after its discovery.
Fast forward a few decades to 2005, and a well-known American chemist, pharmacologist, and author – Alexander Shulgin – took an interest in this long-lost hallucinogen. He theorized that psilomethoxin could be more easily produced by introducing 5-MeO-DMT to magic mushroom substrate, although he never put this theory to practice.
In 2021, entheogen-based spiritual/religious practitioner Ian Benouis picked up where Shulgin’s idea left off. The experiment was successful and Ian, along with his business and research partners Benjamin Moore and Ryan Begin, performed a week-long dieta to learn more about their new substance. Following a successful journey, the group reached out to attorney Greg Lake and launched the Church of Psilomethoxin, with 4-HO-5-MeO-DMT as their sacrament. The Church of Psilomethoxin is a majority veteran-founded organization, and much of its charitable work is directed toward the veteran community with a focus on mental health.
According to Church officials, they continued to conduct experiments with psilomethoxin, mainly in the areas of safety and effects. Between November 2021 and September 2022, over 500 entheogen-based spiritual practitioners took part in their research project and gave detailed reports about their experiences. With very few accounts of negative side effects, the church felt confident enough to open their doors to the public in September 2022.
The future of synthetic psychedelics
After learning about psilomethoxin, the next logical question is whether or not this process would work with other compounds. Imagine growing mushrooms with LSD or mescaline… if that was possible, it would be incredible! Others have theorized about adding kratom to substrate and creating 4-HO-mitragagynine, and the list goes on.
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The reality is, it’s likely to only work with other tryptamine compounds. And while lysergamides are a subset of tryptamines, it’s hard to say if uptake would occur with LSD and if it would undergo the same 4-Hydroxylation that occurrs with 5-MeO-DMT. Mescaline would also be a challenge as phenethylamines likely won’t be taken up by mushrooms.
But back to tryptamines, which are naturally occurring alkaloids found in numerous plants and life forms around the world. There are actually more than 1,500 natural varieties of tryptamine compounds that have been discovered so far. Consider how many orally active tryptamine substances can be created using the mushroom mycelium method. Some have been tested already, such as DET (N, N-diethyltryptamine), which makes 4-HO-DET, but it remains a relatively uncharted sector of the psychedelics industry.
Summarized, psilomethoxin is an edible form of 5-MeO-DMT, and it’s the result of adding 5-MeO to psilocybin mushroom substrate. To clarify, it’s very different than taking 5-MeO and eating some magic mushrooms with it, as the DMT takes over the mushroom and you don’t really get many effects from the psilocybin. What you do get is a slightly milder, yet longer lasting “God molecule” high. It’s very new, so not much is known about it, but as more information becomes available, we’ll be the first to give you all the updates!
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30% Off Liquid Diamonds Live Resin Disposables
Have you tried the new ‘Liquid Diamonds‘ 3G live resin disposables? With an effective blend of THC-X, THC-B, THC-JD, PHC, Delta 8 & Delta 10 these high-potency vapes will take your vaping experience to the next level. Take advantage of our ‘Deal of the day’ and get these strong vapes with an additional 25% discount, using the Delta25 coupon code.
What is live resin and why should you care?
Live resin is a type of cannabis extract that is made using fresh, frozen cannabis plants rather than dried and cured buds. The process of making live resin involves flash-freezing the plants shortly after they are harvested, which preserves the terpenes and other flavorful compounds that can be lost during the drying and curing process. The resulting extract has a distinct, terpene-rich flavor and aroma, and is often used in vaporizers, as well as for making edibles and other cannabis products.
While many disposables use terpenes and some have a great aroma, live resin vape disposables and carts have a distinct flavor which you could almost smell the plant! Choose this product if you want to feel the true flavors of this amazing plant. Take advantage of our ‘d’Deal of the day’ and get the high-potency ‘Liquid Diamonds’ vapes for an additional 25% discount, using the Delta25 coupon code.
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We are excited to announce the arrival of a new and innovative product to the market – the ‘Liquid Diamonds’ live resin disposables, made from potent blend of THC-X, THC-B, THC-jd, PHC, Delta-8 THC, Delta-10 THC, and Live Resin. These cutting-edge disposable vape is designed to deliver the latest and most effective high-potency cannabinoids in a sleek and discreet package.
The live resin disposable vape is a 3-gram vape that comes in a sleek and compact design, making it easy to use and carry around with you wherever you go. The discreet design ensures that you can use it in public without drawing attention to yourself.
This disposable vape is filled with live resin extract, a type of cannabis extract that is known for its high potency and purity. The live resin extract is made from fresh, flash-frozen cannabis flowers, which preserves the valuable terpenes and cannabinoids, resulting in a more flavorful and potent vape experience.
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Three products to choose from: Sativa, Indica and Hybrid
The new ‘liquid Diamonds’ line consists on three live resin disposables to choose from: Cherry Bomb (Sativa), Unicorn Piss (Indica) and Cereal Milk (Hybrid). Each one of them is made by the same effective blend of THC-X, THC-B, THC-jd, PHC, Delta-8 THC, Delta-10 THC, and Live Resin.
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The magical Unicorn Piss strain id a smooth and stimulating Indica strain. Thanks to the live resin, it offers great flavors of citrus and sour notes.
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This well-balanced hybrid strain has notes of creamy vanilla, along with sweet notes of ice cream-like flavors.
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The Cannalope Haze strain is a delicious Sativa strain with a delightful flavor of melons and tropical fruit mix.
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Learn more about live resin disposables
What is THC-X?
THC-X is an invented blend of high-potency cannabinoids that goes into various products in addition to the specified cannabinoids listed. Whenever you see THC-X remember it is not a new cannabinoidThis post contains affiliate links! but an in-house blend that the company has mixed and labeled THC-X. While many companies might use this term ‘THC-X’, each company has its own blend which is unique and you won’t find that formula anywhere else!
What is THC-B?
THC-B AKA Tetrahydrocannabutol, is a psychoactive cannabinoidThis post contains affiliate links! not so different than Delta-9 THC, the ‘regular’ THC we all know from Cannabis. There are many reports on whether it is stronget or weaker than Delta-9, but as everything is so new, we will relate to it as close relative, until we know better. All that said, as with each new cannabinoidThis post contains affiliate links! introduced, you should should always start low and grow slow, until you learn how exactly this specific cannabinoid affects you.
What is THCjd?
Another interestin cannabinoid, which we see in several products is Tetrahydrocannabioctyl (THCjd). Some companies claim that THCjd is up to 19 times more potent than Delta-9 THC. While this might be true, more studies are needed to verify this strong claim. As with THC-B (above) you should take it easy with these new high-potency cannabinoids, and slow down your ‘puffs’ until you find your perfect spot.
What is PHC?
PHC is another new cannabinoidThis post contains affiliate links!, which is very similar to Delta 11. It is claimed that the psychoactive effects from these two cannabinoids have the same intense like the ones coming from edibles, even when they are inhaled, vaped or smoked! That is a very strong claim which will be tested in the next few months. However, if it’s true, it means it is a very high-potency product!
What is Delta 10 THC?
Delta 10 THC is another common cannabinoid extracted from Hemp. Unlike Delta 8, Delta 9 or HHC it is not such a common one to be used in products, but it has its advantages so we are starting to see it more and more in blends.
What are disposables or disposable vapes
Disposable vapes, AKA disposables, disposable e-cigarettes or dispos, are small, discreet electronic device that is used for vaping. Disposables usually consist of a battery, heating element, and a pre-filled cartridge with some e0liquid, such as live rosin liquid diaminds blend in this case. Disposables can be single used or frechargables.
Disposable vapes are very popular as they are discreet, very easy to use and convenient to travel with. The current 3g live resin disposables have a capacity of 3 grams, which is starting to become the new norm. That means you will be able to use for a long time until you run out of product.
What are live resin disposables
Like the name suggested, live resin disposables are filled with live resin extract. Live resin disposables are famous for their great taste and distinct, terpene-rich aroma. They have become very popular among cannabis users who are looking for these specific strong flavors.
What are the benefits of using disposables
There are several benefits of using disposable vapes, including: convenience, portability, cost-effective, variety, discreetness and trendiness.
It’s worth noting that disposable vapes are not sustainable option and are not freindly to the environment, as they are used once and then thrown away.
How should you store live rosin disposables
Disposable vapes should be stored in a cool, dry place to ensure that the extract does not degrade or evaporate. Extreme temperatures, such as high heat or cold, can cause the extract to lose its flavor and potency, and may also damage the battery or other components of the device.
In addition you should keep disposables away from direct sunlight.
When possible try to keep them in their original packaging until you are ready to use them, to protect the device from damage. Keep an eye for the expiration date, also specified on the package.
Unlike carts, disposables are not meant to be refilled or reused.
What are the environmental concerns with disposables
The environmental concerns with disposable vapes include: plastic waste, chemical waste and battery waste. Also currently there are limited recycling options, which is another big issue.
It’s important to be aware of these environmental concerns and to dispose the vapes properly. Some ways to reduce the environmental impact of disposables include: proper disposal and proper battery disposal.
What are the main differences between sativa, indica or hybrid disposables
The main differences between sativa, indica, and hybrid disposables are the effects they produce, which are determined by the strains of cannabis or the terpenes used.
Sativa disposable vapes are producing uplifting and energizing effects. They can provide a boost of creativity, focus and can be used to combat fatigue, depression, and anxiety.
Indica disposable are producing relaxing and sedative effects. They can provide a sense of calm, and can be used to combat insomnia, pain, and muscle tension.
Hybrid disposable can produce effects that are a combination of both sativa and indica strains. They often provide a balanced experience of both energy and relaxation.
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You’ll be the first to know about new arrivals, limited-time deals, and special promotions. This will give you an opportunity to try out new products at a discounted price and make sure you always have the best deals available.
So, don’t miss out on this great opportunity to save big on premium products like this disposable vape and many more. Subscribe to our newsletter today, and start saving on the products you love!
The Positives and Negatives of Magic Mushrooms
Magic mushrooms, like any substance, can be the best or worst drug to take. It really depends on a variety of factors. It’s sometimes hard to find a nuanced view on recreational drugs – especially when many people want to either berate them or promote them beyond belief. The truth is – like people – drugs have their good sides and their bad. In this article we’re going to go through the positives and negatives of these hallucinogenic drugs, with the hope that with this knowledge you’ll be able to create your perfect psilocybin experience. Let’s go.
What are Magic Mushrooms?
There are supposedly around 14,000 species of mushrooms in the world, and only 200 of these are considered ‘magic’. To put this into perspective, around 100 of the 14,000 species are also fatal. You don’t want to mix these guys up. The most common of the magic mushrooms are the Cubensis or golden cap. These have a brown top and long white stem. Magic mushrooms, also known as shrooms, are a type of mushroom that contains the psychoactive compound psilocybin.
This compound is converted into psilocin in the body and is responsible for the hallucinogenic effects of the mushrooms. They can produce altered states of consciousness, including visual and auditory hallucinations and changes in perception. Magic mushrooms have been used for centuries by indigenous people in Central and South America for spiritual and medicinal purposes. It is believed that statues dating back to 200CE exist that highlight the communal use and admiration for the magic plant.
Despite the past, shrooms are now illegal in most of the major nations in the world. In the US, psilocybin is a Schedule I drug and, In the UK, it is considered a class A. These are both on the same level of substances as heroin in regards to severity of sentence and danger. However, in recent years there has certainly been a slow shifting tide. The use of psilocybin in the medical world – specifically in treating mental health issues – has destigmatized the drug. John Hopkins Medicine was heavily involved in these studies and:
“Researchers showed that psychedelic treatment with psilocybin relieved major depressive disorder symptoms in adults for up to a month. Now, in a follow-up study of those participants, the researchers report that the substantial antidepressant effects of psilocybin-assisted therapy, given with supportive psychotherapy, may last at least a year for some patients.”
The effects of magic mushrooms, when paired with therapy, can seriously help people alter their depressive tendencies. It is these kinds of studies, and the acceptance of the benefits of drugs, that highlights the importance of nuance in the drug conversation.
Nuance in Drug Conversation
For too long now, ‘drugs’ have been synonymous with ‘bad’. It is time to open up our minds and see the nuance. Substances have the potential to be dangerous if used incorrectly, whilst also fun and beneficial if used right. Nuance is an important aspect of any discussion, but it is especially crucial when it comes to discussions about drugs. This is because they can have a wide range of effects on the human body and can be used for a variety of purposes. Without nuance, it is easy for a conversation about drugs to become oversimplified or misleading.
The War on Drugs, began by Nixon, is responsible for killing any nuance. He successfully demonized the substances, and many other social groups, for his own political gain. This has lasted generations. It is 2023, and now is the time for us to fully throw away any preconceived ideas we once had about illegal substances, and simply look at the data and studies that are being done. Of course, drugs have hurt and killed people, but so have they helped and saved people. Let’s educate the world openly and use these substances to our own advantage.
Pros & Cons of Shrooms
As we’ve said, nuance is key. Magic mushrooms have the ability to open up people’s minds and fill their lives with joy, but they also can be quite revealing and scary. Hallucinations are not always positive and fun. We’re going to take a look – in a nuanced fashion – at some of the pros and cons of magic mushrooms.
Positives of Magic Mushrooms
Positive side effects of taking magic mushrooms may include:
1 – Creativity
Psilocybin activates receptors in the brain and reduces the energy needed for the brain to switch between activity states. This can increase activity if taken at the right dosage. Many people report feeling more creative and having a greater sense of self-awareness after taking magic mushrooms. This can be helpful for those seeking personal growth or wanting to get something creative done. This is why micro-dosing shrooms have become so popular. Suddenly you’re able to think outside of your usual boxed brain, and can come up with ideas and thoughts that usually aren’t there. Some believe the entire concept of the internet was derived from an LSD trip.
Thank you for dropping in. Head over to the Cannadelics Weekly Newsletter and we’ll update you directly, while offering some sweet promos on cannabisThis post contains affiliate links! flowers, vapesThis post contains affiliate links!, edibles, smoking paraphernalia, cannabinoidThis post contains affiliate links! products (like HHC, delta-8), and a whole lot more. Get yourself stoned responsibly!
2 – Connection
When you take mushrooms, it can Increase the sense of connection to others and the world around you. The borders between these things suddenly vanish, allowing you to realise that we are all one and the same. In other words, ego death. Your individuality no longer matters, you are part of one entity. This can lead to a sense of unity and a feeling of oneness with the universe. It can also seriously improve our relationships with other people in our lives, realising they too are struggling non-egos wandering around this confusing world.
3 – Mental Health Improvement
It is this ego death that can seriously help with reducing anxiety and depression in people who suffer from this. With therapy too, they can move away from their usual thought patterns, and see that the world is not against them. In fact, there is no ‘them’ and never needed to be. The powers of psilocybin allow us to completely shift our minds, realising that our problems, fears and anxieties are not necessarily as important or crippling as we once thought.
Negatives of Magic Mushrooms
Negative side effects of taking magic mushrooms may include:
1 – Hallucinations
On the other hand, hallucinations and distorted perception can also be a difficult thing to experience. One of the main effects of magic mushrooms is the alteration of perception, which depending on your own set and setting, will either be enjoyable or the complete opposite. If you are not in the ideal mindset or location, it is possible that your visions may become unpleasant. They may become overwhelming or even frightening. This is why set and setting is so integral to any trip embarked on.
2 – Paranoia
Another negative of this psychedelic drug that can occur is paranoia and anxiety. The unpleasant hallucinations can easily lead to these feelings. Suddenly you become afraid of what might arise in you, or what you might do or say. You no longer feel free and spirited, instead you feel out of control. Being out of control is not something we are used to as people in a constricted and structured world, which is why it’s always good to have a trip sitter with you. They can ensure you stay safe.
3 – Nausea
Magic mushrooms aren’t the best tasting plants. In fact, it can be quite disgusting eating a few grams of these. They taste like sour soil with a consistency of a mushy potato. Basically not ideal. In addition, when they settle in your stomach, they don’t always agree with everyone. Magic mushrooms can cause nausea and vomiting in some people, particularly if they are consumed in large amounts. The key is to have a drink with you and eat them slowly.
These were some of the positives and negatives of magic mushrooms, laid out in a nuanced way. This is because magic mushrooms can be amazing, but they can also be dangerous if used incorrectly. It is time for us to understand both realities at the same time. As with any psychoactive substance, it is important to use caution and to be aware of the potential risks. But it’s also vital that we allow these specimens to have the medical and recreation benefits that they’ve been giving us for centuries. It’s time to befriend the shroom, not outcast it. Nonetheless, in 2023, the future of psilocybin is beginning to look bright.
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15% Discount On Premium THCA Flower
Have you tried the new exciting THCA flower, finally available online? Our deal of the day allows you to buy premium THCA flower with an additional 15% discount, using the Delta15 coupon code. Take advantage of this offer and have this attractive product shipped directly to your home.
What is THCA flower and is it different than cannabis?
THCA flower is NOT cannabisThis post contains affiliate links!, as the level of Delta-9 THC are below the legal levels. However, as THCA is converted to THC when it is heated (as when you smoke or vape THCA flower), the effects are very similar than the ones you get when smoking cannabis. Other than the differences in the legal status, for all other matters, smoking THCA flower is the same as smoking cannabis, so expect to get high, even that formally yop will be smoking hemp…
THCA Flower (AKA THCA Hemp Flower) is a very potent flower, that is only legal thanks to the many loopholes brought to us by the 2018 Farm Bill. People who have been using it report that it is giving an amazing body and mental experience. As it is officially still hemp, you can buy these flowers, and get it mailed to your home, even if you live in a state where cannbis isn’t legal. However, as it is bought online, you don’t have to pay the additional taxes, applied to the products in the dispensary, where cannabis is legaly sold.
Want to try the new THCA flower? Take advantage of our deal of the day and get these high-potency products with an extra 15% discount, using our Delta15 coupon code.
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As always, the best deals on THCA flower as-well as on other THCA products such as THCA carts, THCA disposables and THCA dimonds are offered first to the subscribers of the Cannadelics Newsletter.
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As THCA flower are legal, you can order them online. However, when heated THCA is converted into Delta-9 THC, so smoking THCA flower have almost the same effects like smoking cannabis…
This nice loophole allows anyone, even if you live in a state where cannabis isn’t legal, to order THCA flower online. In addition, as it is sold online, you could get it for a great price. Add to it our 15% discount (using the Delta16 coupon code) and you have a true winner.
Choose between: Grape Frosty (Indica), Han Solo (Indica) and MAC – Miracle Alien Cookies (Hybrid).
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What is THCA?
THCA (tetrahydrocannabinolic acid) is the precursor to Delta-9 THC, the leading psychoactive cannabinoidThis post contains affiliate links! in cannabis. In its raw form THCA isn’t psychoactive, but when it is heated (for examples when you smoke or vape THCA flower), ir is converted into Delta-9 THC and the product becomes psychoactive. People who use THCA claim that THCA products, such as THCA carts, THCA disposables, THCA diamonds and THCA flower, are very potenct and have the same effects like using regular Delta-9 THC.
How do you use THCA flowers
- THCA flowers, can be consumed in a number of ways, some of which include:
- Smoking: THCA flower can be smoked.
- Vaporizing: THCA flowers can be vaporized using a vaporizerThis post contains affiliate links! or vape pen
- Eating: THCA flowers can be consumed by eating them, when they are added to another food.
- Juicing: THCA flowers can be juiced and consumed as a juice.
- Tinctures: THCA flowers can be used to make tinctures.
- Topical: THCA flowers can be used to make topical products.
How do you store THCA flowers
Proper storage of THCA flowers is important to ensure that they remain fresh and effective. Here are a few tips for storing THCA flowers:
- Keep them in a cool, dark place and make sure they avoid direct sunlight or in hot
- Keep them in an airtight container and avoid humid environments
- Avoid extreme temperatures, both cold or hot.
- Keep them away from children and pets…
- Keep an eye on the expiration date
By following these guidelines, you can help ensure that your THCA flowers remain fresh and effective for as long as possible.
What are the medical benefits of using THCA flowers
The medical benefits of using THCA flowers are still being studied and are not fully understood. Some of the potential therapeutic benefits of THCA include: Anti-inflammatory effects, Anti-spasmodic effects, Anti-tumor effects and Appetite-stimulating effects.
It’s important to note that the research on THCA is still in its early stages and more studies are needed to fully understand its effects and potential therapeutic uses. It’s always recommended to seek the advice of a healthcare professional before starting any new treatment with THCA flowers or any cannabis-related products.
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How do you smoke THCA flowers
Smoking THCA flowers involves heating them in order to convert the THCA into THC, so you can get high. If you never smoked cannabisThis post contains affiliate links! before, just follow the steps below:
- Grind the flowers and break them into small, manageable pieces.
- Pack a pipe or roll a joint with the ground THCA flowers.
- Light up and inhale the smoke.
- Take small puffs and wait a few minutes to see how it affects you before taking another puff.
As you are moving to the next joint, keep track of the amount of THCA/THC you are consuming and the effects that it is having on you. Look for that sweet spot you don’t need to smoke more, to avoid ‘wasting medicine’.
Will smoking THCA flower make you fail a drug test?
As THCA converts into THC when heated, smoking THCA flower might make you fail a drug test. It is highly recomended, that you pause smoking long-enough before the test. However, the exact length of time required to stop smoking THCA flower in order to test negative on a urine drug test depends on several factors: the individual’s metabolism, the frequency of use, the amount you have smoked, and the specific test being used. Additionally, there are several other factors that can affect the result of the drug test, including the individual’s metabolism, hydration levels, and overall health.
As a general rule, you might want to stop smoking both THC and THCA flower, as well as using any other THC-containing products at least 2-4 weeks before the test. However, for heavy users, that have been smoking daily, longer period of time might be advised.
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What are Sativa, Indica and Hybrid strains?
There are many different strains of cannabisThis post contains affiliate links!, each with their own unique characteristics and effects. Sativa, Indica, and Hybrid are the three main types.
Sativa: Sativa strains are known for their uplifting and energizing effects. They typically have high levels of THC and lower levels of CBD. They are known for their cerebrally focused effects which can lead to increased creativity, focus and euphoria. Strains such as Jack Herer, Durban Poison, and Green Crack are all Sativa strains.
Sativa strains are traditionally taller and thinner than Indica strains, and they have longer flowering times.
Indica: Indica strains are known for their relaxing and sedating effects. They typically have high levels of THC and lower levels of CBD. They are known for their physically focused effects which can lead to increased relaxation, sleepiness, and pain relief. Strains such as OG Kush, Granddaddy Purple, and Blueberry are all Indica strains.
Indica strains are usually shorter and bushier than Sativa strains, and they have shorter flowering times.
Indica strains are known for their relaxing and sedating effects. They Indica strains are often used to help with pain, anxiety, insomnia, and relaxation.
Hybrid: Hybrid strains are a cross between Sativa and Indica strains and can have effects that are a combination of both. They can vary in ratio of sativa to indica and can have different levels of THC and CBD depending on the cross. Strains such as Girl Scout Cookies, Gorilla Glue and Blue Dream are all Hybrid strains.
CBD-dominant strains: These strains are characterized by having high levels of CBD and low levels of THC. They are known for their medical benefits and for not having the “high” feeling associated with THC. Strains such as Charlotte’s Web, Harlequin, and ACDC are all CBD-dominant strains.
All that said, today this old definition is no longer valid, as most of the plants have been lo ago, mixed and remixed so in a way, they are hybrids… It’s also worth noting that the names of the strains can vary depending on the breeder or the location where it’s sold.
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What are terpens?
Terpenes are a class of organic compounds that are found in many plants, including cannabis and hemp. They are responsible for the distinct aromas and flavors of different cannabis strains, and they are also believed to have some therapeutic effects.
Some of the most common terpenes found in hemp/cannabisThis post contains affiliate links! and their effects include:
Limonene: This terpene has a citrusy aroma and is known for its mood-enhancing and stress-relieving effects. It might also have anti-inflammatory and pain-relieving properties, but this is needed an additional research.
Myrcene: This terpene has an earthy, musky aroma and is known for its sedating and relaxing effects. It is also believed to have pain-relieving and anti-inflammatory properties.
Pinene: This terpene has a pine-like aroma and is known for its anti-inflammatory and pain-relieving properties. It might also be tru that it helps with alertness and memory retention.
Linalool: This terpene has a floral aroma and is known for its relaxing and sedating effects. It might also has pain-relieving and anti-anxiety properties.
Caryophyllene: This terpene has a spicy, woody aroma and is known for its pain-relieving and anti-inflammatory properties. It also helps with reducing anxiety and depression.
What are the risks of smoking THCA flowers
Smoking THCA flowers, like any other form of smoking, can have some risks, among them: Lung irritation and inflammation of the lungs, respiratory issues, cardiovascular issues, interaction with other substances and in rare cases, addiction. Smoking isn’t healthy and always prefer using dry herb vaporizers when possible, even it also has its risks.
It’s important to note that smoking any substance can be harmful to the lungs.
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